保志军
点击：10次 发布/更新时间： 2023-06-27
保志军
主任医师，教授，博士生导师
四海资讯红足附属华东医院，四海资讯红足
联系方式：办公室电话（021）62498577
Email: zhijunbao@fudan.edu.cn
研究方向：老年衰弱护理的循证决策研究、循证护理研究、慢病管理
教育背景
1993年毕业于上海交通大学医学院（原上海第二医科大学）临床医学专业，获学士学位
1998年毕业于四海资讯红足公共卫生事业管理专业，获硕士学位
2006年毕业于上海交通大学内科学（消化）专业，获博士学位
教学及科研情况
开设《老年医学临床实践》、《老年基础医学进展》研究生和本科生选修课，其中《老年医学临床实践》为市教委重点课程。承担《内科学C》、《诊断学》、《老年医学临床决策及案例解析》等课程的教学，出版科普书籍《知行合一健康百岁——老年居家健康自我管理手册》、《幽门螺杆菌感染Q&A》、《细说肌少症》等。是四海资讯红足内科学（消化）和老年医学的跨专业博导。
现为上海老年医学领域学科带头人、国家重点研发项目首席，入选上海医学领军人才，上海市健康科普引领人才，担任国家老年疾病临床医学研究中心副主任、上海市老年医学临床重点实验室主任。近五年来获得国家科技部重点研发计划重点专项、国家自然科学基金、上海市科委、上海市卫健委、上海市教委等基金项目资助，研究课题包括中国老年人衰弱的标准及综合干预研究、脂肪肝细胞衰老相关作用机制研究、老年健康评估体系、老年人肌少症综合干预研究、老年衰弱护理的循证决策研究、循证护理研究等。近年来在国内外核心期刊中以第一作者或通讯作者发表论文100余篇，其中SCI论文29篇，授权国家发明专利8项。指导博士后、博士及硕士研究生近五十名。
曾荣获2017年、2022年上海市级教学成果奖二等奖，2021四海资讯红足研究生教学成果奖二等奖，2021年上海医学科技奖二等奖，2019年上海中医药科技奖三等奖，2018年上海市护理科技奖，2017年四海资讯红足教学成果奖一等奖。
学术任职
现任四海资讯红足附属华东医院副院长。
兼任中国老年医学研究机构联盟副主任委员，中国老年学和老年医学学会衰老抗衰老委员会副主任委员，中国老年学和老年医学学会慢病分会常委，上海老年学学会副会长，上海老年学会老年医疗保健专业委员会主任委员，上海市医学会常务理事。
担任《老年医学与保健》编辑部主任，《中华消化杂志》、《复旦学报（医学版）》、《上海医学》等10本杂志编委。
近五年主要论文
Chaobao Zhang,&; Hongzhi Wang,&; Zilu Wen,&; Zhijun Bao*, Xiangqi Li4* ,View author affiliations. Collective and Individual Assessment of the Risk of Death from COVID-19 for the Elderly, 2020–2022[J]. China CDC Weekly, 2023, 5(18): 407-412.
Xueying Ji, Xin Jiang#, Fan Yang, Jiaming Yu, Mengjuan Xue, Zhijun Bao*. Galectin-3 regulates skeletal muscle loss via TGFβ1-Smad2/3 signaling activation in mice. Archives of Medical Science，2023
Fangyuan Dong#, Hui Li#, Limin Liu6#, Linli Yao#, Jiaofeng Wang, Danni Xiang, Jianxia Ma, Gansheng Zhang, Shan Zhang, Jun Li, Shu-Heng Jiang*, Xiaona Hu*, Jie Chen*, Zhijun Bao*. ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1α activity. International Journal of Biological Sciences，2023; 19(8): 2613-2629.
Bo Ye, Yi Wang, Hao Chen , Yingwei Chen , Huihui Yan, Hua Fu , Zhijun Bao*, Junling Gao* ,Development and Validation of the Chinese Frailty Screening Scale: A Study among Community-Dwelling Older Adults in Shanghai, Int J Environ Res Public Health. 2022 Sep 19;19(18):11811
Yuxin Huang, Xudan Lou, Cuiping Jiang , Xueying Ji, Xiaoming Tao* , Jiao Sun , Zhijun Bao* ,Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes, Front Endocrinol (Lausanne). 2022 Nov 17;13:1044030
Huiyuan Yu, Xin Jiang,Fangyuan Dong, Fan Zhang, Xueying Ji , Mengjuan Xue, Fan Yang, Jie Chen*, Xiaona Hu*, Zhijun Bao*, Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway, xp Cell Research. 2021 Aug 15;405(2):11268
Huiyuan Yu, Fan Yang, Wentao Zhong, Xin Jiang, Fan Zhang, Xueying Ji , Mengjuan Xue , Yixuan Qiu , Jiaming Yu , Xiaona Hu*, Jie Chen*, Zhijun Bao*, Secretory Galectin-3 promotes hepatic steatosis via regulation of the PPARγ/CD36 signaling pathway, Cell Signalling. 2021 Aug;84:110043.
Fangyuan Dong, Rongkun Li, Jiaofeng Wang, Yan Zhang, Jianfeng Yao, Shu-Heng Jiang, Xiaona Hu, Mingxuan Feng, Zhijun Bao* .Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research. 2021 Apr 8;40(1):121
Fan Yang , Fan Zhang , Xueying Ji , Xin Jiang, Mengjuan Xue , Huiyuan Yu , Xiaona Hu, Zhijun Bao* .Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells. Journal of Biological Chemistry, 2020 Dec; 4;295(49):16852-16862
Yixuan Qiu , Jiaming Yu , Yi Li 4 5, Fan Yang , Huiyuan Yu , Mengjuan Xue , Fan Zhang, Xin Jiang, Xueying Ji , Zhijun Bao*. Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling. Annals of Medicine. 2021Jan;53(1):508-522
Mengjuan Xue, Fan Zhang , Xueying Ji , Huiyuan Yu Xin Jiang Yixuan Qiu, Jiaming Yu , Jie Chen , Fan Yang, Zhijun Bao*. Oleate Ameliorates Palmitate-Induced Impairment of Differentiative Capacity in C2C12 Myoblast Cells. Stem cells and development. 2021Mar;30(5):289-300
Xin Jiang , Fan Zhang , Xueying Ji , Fangyuan Dong , Huiyuan Yu , Mengjuan Xue , Yixuan Qiu, Fan Yang , Xiaona Hu, Zhijun Bao*. Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and. Cytokine, 2021Jun;142:155474.
Fan Zhang, Mengjuan Xue, Xin Jiang, Huiyuan Yu, Yixuan Qiu, Jiaming Yu, Fan Yang, Zhijun Bao*. Identifying SLC27A5 as a potential prognostic marker of hepatocellular carcinoma by weighted gene co-expression network analysis and in vitro assays. Cancer Cell International. 2021Mar;17;21(1):174
Min Zhang, Zhaori Bi, Xinping Fu, Jiaofeng Wang, Qingwei Ruan, Chao Zhao, Jirong Duan, Xuan Zeng, Dian Zhou, Jie Chen, Zhijun Bao*. A parsimonious approach for screening moderate-to-profound hearing loss in a community-dwelling geriatric population. BMC Geriatrics. 2019 Aug; 7;19(1):214
Yuxin H, Cuiping J, Wen T, Jieyuzhen Q, Xiaoming T, Qin G, Haidong W, Jiao S, Zhijun B*. Comparison of gastrointestinal adverse events with different doses of metformin in the treatment of elderly people with type 2 diabetes. Journal of Clinical Pharmacy and Therapeutics. 2020 Jun;45(3):470-476
Ying Zhang , Danni Xiang , Xiaona Hu , Qingwei Ruan , Lina Wang , Zhijun Bao* . Identification and study of differentially expressed miRNAs in aged NAFLD rats based on high-throughput sequencing. Annals of Hepatology. 2020 May;19(3):302-312
Dong Fangyuan,Yang Qin, Wu Zheng, Hu Xiaona, Shi Dongmei, Feng Mingxuan, Li Jun, Zhu Lili, Jiang Shuheng*, Bao Zhijun*. Identification of survival-related predictors in hepatocellular carcinoma through integrated genomic, transcriptomic, and proteomic analyses. Biomedicine & Pharmacotherapy, 2019, 114: 108856.
Fangyuan Dong, Shuheng Jiang, Jun Li, Yahui Wang, Lili Zhu, Yiqin Huang, Xin Jiang, Xiaona Hu*, Qi Zhou*, Zhigang Zhang*, Zhijun Bao*. The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway. EBioMedicine, 2019, 39:472-483.
